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Although electronic computers are the only
"computer species" we are accustomed to, the mathematical notion
of a programmable computer has nothing to do with wires and
logic gates. In fact, Alan Turing's notional computer, which
marked in 1936 the birth of modern computer science and still
stands at its heart, has greater similarity to natural biomolecular
machines such as the ribosome and polymerases than to electronic
computers. Recently, a new "computer species" made of biological
molecules has emerged. These simple molecular computers inspired
by the Turing machine, of which a trillion can fit into a microliter,
do not compete with electronic computers in solving complex
computational problems; their potential lies elsewhere. Their
molecular scale and their ability to interact directly with
the biochemical environment in which they operate suggest that
in the future they may be the basis of a new kind of "smart
drugs": molecular devices equipped with the medical knowledge
to perform disease diagnosis and therapy inside the living body.
They would detect and diagnose molecular disease symptoms and,
when necessary, administer the requisite drug molecules to the
cell, tissue or organ in which they operate. In the talk we
review this new research direction and report on preliminary
steps carried out in our lab towards realizing its vision.
REFERENCES
Benenson Y., Paz-Elitzur T., Adar R., Keinan E,
Livneh Z. and Shapiro E. (2001)
Programmable and autonomous
computing machine made of biomolecules. Nature,
414, 430-434.
Benenson Y., Adar R., Paz-Elitzur T., Livneh Z.,
and Shapiro E. (2003) DNA molecule
provides a computing machine with both data and
fuel. PNAS, 100, 2191-2196.
Adar R., Benenson Y., Linshiz G., Rozner A., Tishby
N. and Shapiro E. (2004) Stochastic
computing with biomolecular automata. PNAS, 101,
9960-9965.
Benenson Y., Gil B., Ben-Dor U., Adar R., and
Shapiro E. (2004) An autonomous molecular
computer for logical control of gene expression.
Nature, 429, 423-42.
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